FAQ
Log In
Thursday 21st August 2014
News
 › 
 › 

Smoking and cancer insight

8th August 2006

Studies reported by US researchers online by the Journal of Clinical Investigation give a new understanding of the molecular mechanisms underlying nicotine's ability to induce tumour cell proliferation and progression.

They suggest that nicotine functions like a growth factor; the presence of nicotinic acetylcholine receptors (nAChRs) are key players in nicotine-induced cell proliferation. nAChRs bind nicotine, they are present on bronchial cells as well as on lung cancer cells.

The authors say that there is no evidence that nicotine contributes to the induction of tumours, but it has been demonstrated that nicotine promotes the growth of solid tumours in vivo.  This suggests that nicotine might be contributing to the progression of tumours already initiated.

The researchers showed that stimulation of non-small cell lung cancer (NSCLC) cells, as well as bronchial cells, with physiologic doses of nicotine leads to robust cell proliferation that is dependent on nAChRs.

Share this page

Comments

There are no comments for this article, be the first to comment!


Post your comment

Only registered users can comment. Fill in your e-mail address for quick registration.

Your email address:

Your comment will be checked by a Healthcare Today moderator before it is published on the site.

Mayden - Innovative cloud-based web development for the healthcare sector
© Mayden Foundation 2014