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Friday 28th October 2016

Gene found that protects against lung cancer

2nd December 2008

Researchers at the University of Nottingham say they have found a gene which offers protection against lung cancer.


The gene, LIMD1, acts to suppress tumours and could be used to help develop new ways of treating the disease.

Lung cancer causes 33,600 deaths annually in the UK and is often diagnosed once it is at a advanced stage.

It is believed that 90% of lung cancer cases are caused because patients smoked.

The study was published in Proceedings of the National Academy of Sciences and explained how scientists made comparisons between tissues in lung cancer and tissues in normal lungs.

The team saw that many of the lung cancer samples did not contain the LIMD1 gene, which showed it could aid the body in fighting the disease.

They followed the experiment with one where mice were specially bred without the gene and developed cancer.

Lead researcher Dr Tyson Sharp said: "The LIMD1 gene studied in this research is located on part of chromosome 3, called 3p21."

"Chromosome 3p21 is often deleted very early on in the development of lung cancer due to the toxic chemicals in cigarettes, which implies that inactivation of LIMD1 could be a particularly important event in early stages of lung cancer development."


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