Log In
Tuesday 24th April 2018

Genes for sight defect found

7th March 2006

Research by a team at New York's Columbia University suggests that nearly three-quarters of cases of one of the world's most common causes of blindness, age-related macular degeneration (AMD) are linked to just two genes. AMD causes blindness in millions of older people across the globe. They hope their work could help aid the development of new treatments for the condition.

Previous work had shown that several variants of a gene called Factor H significantly increase the risk of AMD. The latest research focused not only on Factor H, but on other genes that play a role in the same immune response pathway. A genetic analysis of 1,300 people identified a second gene, Factor B, as playing a significant role. While Factor H is an inhibitor of the immune response to infection, Factor B is an activator.

Because of the complementary roles of the these two genes, a protective Factor B variation can protect against AMD, even if one carries a risk-increasing variant of Factor H, and vice versa.

The researchers are now searching for the specific triggers that set off the immune response, and subsequent inflammation.


Share this page


There are no comments for this article, be the first to comment!

Post your comment

Only registered users can comment. Fill in your e-mail address for quick registration.

Your email address:

Your comment will be checked by a Healthcare Today moderator before it is published on the site.

Article Information

Title: Genes for sight defect found
Author: Sarah Jackson Han
Article Id: 103
Date Added: 7th Mar 2006


BBC News

Recent Related Articles

Uncommon rheumatoid arthritis sign linked to eyes


Add to scrapbook
Show Comments
Add comment
Find all related articles


M3 - For secure managed hosting over N3 or internet
© Mayden Foundation 2018