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Hope after thalidomide find

12th March 2010

Scientists have made a breakthrough that could lead to the development of safer thalidomide-like drugs.

Research in the journal Science has shown that scientists have discovered the primary mechanism by which thalidomide causes malformed limbs in developing embryos. Thalidomide – which can be effective in treating cancers and leprosy - binds to and renders inactive the protein cereblon, which is very important in limb formation. Medical researchers want to develop drugs that mimic the action of thalidomide, but do not affect limb development.

 

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