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Kidney risk link to drug combo

8th February 2008

Researchers in the UK have said use of the clotting drug aprotinin in combination with angiotensin-converting enzyme (ACE) inhibitors during cardiac operations leads to a danger of kidney problems.

Researchers from the department of anesthesia, at Bristol Royal Infirmary, looked at data from 9,875 cardiac surgery patients. Aprotinin was linked with double the risk of renal dysfunction in those patients who also received ACE inhibitors. The study was published in The Lancet this week.




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