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Friday 28th October 2016

New drug fights breast cancer

10th October 2006

19092006_vitamin_D.jpgA new drug, capable of halving the speed of the growth of breast cancer, could be available to British women within months.

Tykerb (also known as Lapatinib) has been hailed a ‘wonder drug’ as it seeks out cancer cells and attacks them from within.  The new drug is thought to give those in the late stages of breast cancer several extra months to live.

Taken once a day, Tykerb tablets can halve the speed of the growth of the disease by killing rogue body proteins which fuel the growth of at least one third of breast cancers.  Trials in hundreds of women have shown that Tykerb slows down the progression of the advanced form of two types of breast cancer.

GlaxoSmithKline is applying for a licence for the new drug and hopes it will be available to women in the late stages of the disease by early next year.   Following further research, it could be cleared for use in women with early stage breast cancer by 2009.  Trials of the drug have shown it to be effective in women who have become resistant to Herceptin.

Tykerb, which will not initially be available on the NHS, has also shown promise in fighting brain, liver and kidney cancers.


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Marie Gilberti

Wednesday 14th March 2007 @ 12:29

My husband has stage 4,bone mets,her-2 positive cancer. He was diagnosed Sept 7, 2006 and this appears to be the miracle he is we are waiting for.
Right now he is responding to treatment(Taxotere) and gets Herceptin weekly through portacath, monthly has Zometa. Diet and excersise has kept him away from most Procrit injections.
Help us please!!! When he gets into remission, we will be helping to help others through this horrific disease and starting our own MALE BREAST CANCER website. Kudos to you all wonderful Angels who have come to our rescue and may God Bless You All!! If you need help to study males in this catagory, please e-mail us back. After all Breast Cancer is not a female disease; it is a human disease and MEN GET BREAST CANCER TOO!! Thank you again, Mgilberti

Carol Nicosia

Wednesday 21st March 2007 @ 22:13

I have HER2 breast cancer. Since reading an article in Cure magazine regarding HER2 and the fact that Tykerb was in clinical trials, I have been waiting for the FDA approval. According to the article, Herceptin alone does not efficiently attack the HER2 cell, only certain proteins in the cell. I finished the year regime of the Herceptin in December so I am feeling vulunerable.

Lisa Partington

Thursday 26th April 2007 @ 0:00

Does anyone know if Tykerb causes ankle swelling?


David Edwards

Wednesday 2nd May 2007 @ 21:02

Lapatinib may work but it is served up with a side order of Capicitabine. Its a bit like claiming that you have a fast car but it needs another car to pull it. Can anyone explain this please as my wife has been accepted for a trial and is very uncertain?

Wednesday 23rd May 2007 @ 15:38

Lapatinib(Tykerb) and Capicitabine (Xeloda) work in very different ways. At the moment this particular combination is the one that has been put through clinical trials. That is not to say that other chemos or even Herceptin in conjunction with Tykerb might not work equally well. The cost and time constraints of each trial often make it difficult to expand the studies once approval has been granted and so specific combinations are approved one at a time. The Tykerb works from inside the cell to prevent errant cancer cells from breaking through its pathway, thereby travelling through the system to distant organs. The Xeloda's role is to kill the cancer cells. It has also been proven that the combination of Tykerb and Xeloda is more effective better than each on its own. One problem with this combination is that Xeloda has been approved for use at a very high dose. In most cases much higher than anyone can tolerate. Further trials to lower the recommended dose have not been done for financial reasons and time constraints. It is often a matter of trial and error to see how much the patient can tolerate. It is known, however, that it can be just as effective at a lower dose than a higher one so don't be concerned if your doctor lowers the dose once you start your treatment. I have been on this combination for 5 weeks and seem to be tolerating it well. Tykerb, like Herceptin seems to have the effect of giving an extra boost to the chemotherapy.

christine adams

Thursday 12th July 2007 @ 4:57

I have seen on chemo for breast cancer since March 1998. Started getting Herceptin in 2000 along with Taxotare. Then only Herceptin and then off Herceptin for maybe 1 yr, then back on Herceptin and Taxol. Recently started getting severe flu like symptions and doctor is talking about putting me on Tykerb but not with Xeloda. I didn't tolerate Xeloda well in the past and was on it a short time - maybe dose too high - don't know. Any feedback welcomed - I was so comfortable and confident with Herceptin.

Sunday 22nd July 2007 @ 20:31

This is to Lisa who posted on April 26th 2007.
My mom began Tykerb a month ago and although she already had a severe case of lymphedema due to radiation to her hip, over the past week or so her calves, ankles, and feet have become so swollen that it is extremely difficult to even put on her shoes. We met with her oncologist this past week and since the drug is so new, he wasn't sure if swelling was a side effect. Now that I read your comment, I wonder......


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