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Tuesday 25th October 2016

Prostate cancer marker identified

9th May 2006

A study published online by Nature Genetics identified a genetic marker for prostate cancer.  The research involved a genome-wide linkage scan for 871 men with prostate cancer from 323 extended families.

The authors identified a suggestive linkage signal on chromosome 8q24; they conducted one case control study with African American men, and three case-control studies with men of European ancestry. The estimated population attributable risk was 16% among African-Americans versus 5% to 11% among men of European ancestry.

The authors say that the 'relatively high' population frequency of the - 8 allele in African Americans, 'confers an estimated population attributable risk of about 16% and could alone produce more than a 10% greater incidence of prostate cancer in African Americans than in European Americans'.

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