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Scientists discover new preventative strategies for stroke

25th March 2014

A US-study of 5,000 people's genomes has pinpointed a genetic variant tied to an increased risk of stroke. They have also uncovered new details about a reaction in cells that play a major role in several common diseases.

Stroke news

Together these results may provide new clues to underlying genetic and biochemical influences in the development of stroke and cardiovascular diseases and may help to find treatment strategies.

The study was published in the journal PLoS genetics.

Dr Williams*, one of the leading scientists involved, said that the goal of the study was: "to break down the risk factors for stroke".

There are numerous genetic and environmental factors that can contributed to a person having a stroke. Strokes are currently the fourth leading cause of death and a major cause of adult disability in the US. Yet its underlying genetics have been difficult to understand.

The scientists already knew that abnormally high blood levels of amino acids are associated with an increased risk of common diseases such as stroke, cardiovascular disease and dementia.

But they have now identified specifically the ALDH1L1 gene. This particular gene, if not working properly, has been associated with a breakdown in a normal cellular processes called "programmed cell death" and "cancer cell survival".

This particular research has paved the way for more research that can identify further, the affects of the ALDH1L1 gene.

For more detailed information view the source

*Stephen Williams, PhD, a postdoctoral fellow at the University of Virginia Cardiovascular Research Center and the University of Virginia Center for Public Health Genomics, Charlottesville.

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