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Wednesday 21st August 2019

Soluble vaccine developed

25th October 2012

Researchers have developed a new way of delivering vaccines that avoids having injections.

The method, which will be good news for people who avoid inoculations because of a fear of needles, can deliver a variety of vaccines directly into the bloodstream via a soluble film placed under the tongue or by nasal spray.

Devised by a team at the Royal Holloway, University of London, it utilises ‘good bacteria’ to administer vaccines against flu and tuberculosis.

Professor Simon Cutting of Royal Holloway said: “Rather than requiring needle delivery, vaccines based on Bacillus spores can be delivered via a nasal spray or as an oral liquid or capsule.

“Alternatively they can be administered via a small soluble film placed under the tongue in a similar way to modern breath fresheners.

“As spores are exceptionally stable vaccines based on Bacillus do not require cold-chain storage alleviating a further issue with current vaccine approaches.”

It is less painful than injections, safer to administer and more cost-effective as such vaccines will be easier to store and keep fresh.

With trials already conducted to determine the effectiveness of Bacillus based vaccines for different diseases, the research team is now examining whether it can be used against Clostridium difficile, which causes around 50,000 infections and 4,000 deaths a year in the UK but currently with no vaccine available against the disease.

“Bacillus based vaccines offer distinct advantages as unlike other approaches, oral delivery can cause a more specific immune response in the gastrointestinal tract to fully eliminate C. difficile,” said Professor Cutting.


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