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Saturday 22nd October 2016

Warning signs for diabetes detected

9th June 2009

Researchers led by University College London have said changes in the body's chemistry can be detected years before the symptoms of type 2 diabetes become evident.


The Lancet study showed that a change in blood glucose levels and insulin sensitivity could be detected in people who developed the condition.

The researchers studied 6,538 civil servants over nearly a decade and saw 505 cases of type 2 diabetes within the group.

They looked at how the participants' blood glucose levels altered, how the beta-cells of the pancreas worked and how their sensitivity to insulin changed over the years.

The team found that the participants who did not develop the condition showed "steady" changes in body chemistry over the ten years.

In contrast, participants who developed diabetes showed a quick increase in glucose levels - both when they had not eaten and after a meal - up to three years in advance of the condition being diagnosed.

The team also saw a steep decrease in insulin sensitivity in the diabetic patients which began five years before diagnosis.

Lead researcher Dr Adam Tabak said: "Our model may help detect people at high risk to develop diabetes, so we can better target these people to prevent the development of the disease."

"We believe that an earlier intervention - before the conventional prediabetes stage - could delay diabetes development substantially."


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